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  • 盡管CD14在大多數(shù)細(xì)胞中表達，但與MHC中Ⅰ比較，其表達程度受到一定限制。組織特異性的基因表達由其染色質(zhì)的結(jié)構(gòu)和DNA甲基化狀態(tài)所決定。CD14分子的限制性表達也由組織特異性核轉(zhuǎn)錄因子或由共同核轉(zhuǎn)錄因子的特異性聯(lián)合所決定。如PU.1僅在單...

  • 在單核細(xì)胞、巨噬細(xì)胞、中性粒細(xì)胞中，CD14的合成和表達可以受到不同介質(zhì)的調(diào)節(jié)和改變，如在中性粒細(xì)胞中，TNF-α、G-CSF、甲酰蛋氨酸-亮氨酸-苯丙氨酸（formylmethionyl-leucyl-phenylalanine，f-ML...

  • 人類的CD14基因位于5號染色體，位點為5q23-31。依據(jù)CD14的cDNA序列，CD14由356個氨基酸所組成，在核糖體合成多肽后，再轉(zhuǎn)運到高爾基復(fù)合體發(fā)生糖化反應(yīng)，故CD14為一種糖蛋白。CD14的N端前導(dǎo)肽（leaderpeptid...

  • 1982年，研究者在巴黎首屆白細(xì)胞分型研討會上提出了CDw14分子（w代表workshop，研討會）的概念，隨后研究者們對CDw14分子的功能進行了廣泛研究，并于1989年正式命名CD14分子。CD14抗原是機體免疫反應(yīng)過程中的關(guān)鍵分子之一...

  • 機體能夠及時地識別LPS（脂多糖，lipopolysaccharide）的存在，如血清中的游離型LPS或革蘭陰性細(xì)菌細(xì)胞膜上的LPS，是機體發(fā)揮天然免疫的首要環(huán)節(jié)之一。天然免疫中的模型識別受體（patternrecognitionrecep...

  • LBP（脂多糖結(jié)合蛋白，lipopolysaccharide-bindingprotein）與LPS（脂多糖，lipopolysaccharide）結(jié)合形成LPS-LBP復(fù)合物后，再與紅細(xì)胞等顆粒物質(zhì)結(jié)合；LBP也可以直接與紅細(xì)胞等顆粒物質(zhì)...

  • LBP（脂多糖結(jié)合蛋白，lipopolysaccharide-bindingprotein）與LPS（脂多糖，lipopolysaccharide）結(jié)構(gòu)中的脂質(zhì)A部分具有高度親和性，能夠識別和結(jié)合LPS，形成LPS-LBP復(fù)合物。一方面LB...

  • LBP（脂多糖結(jié)合蛋白，lipopolysaccharide-bindingprotein）主要由肝細(xì)胞合成、分泌。人類肝細(xì)胞內(nèi)LBP基因位于20號常染色體的長臂端q11，23和q12之間；人和兔的LBP基因已被克隆，其核苷酸序列也已闡明。...

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